In this study, the goal was to create and assess orodispersible tablets of losartan potassium using banana powder as a natural superdisintegrant alongside sodium starch glycolate, a synthetic superdisintegrant.The goal was to create a formulation that would break down quickly and make it easier for patients to follow the instructions, using a delivery method that was both cost-effective and easy for patients to use. The tablets were made with a single-punch tablet machine and the direct compression method. Seven batches were made in all (F1 to F7), each with a different amount of banana powder, sodium starch glycolate, or a mix of the two. Fourier Transform Infrared (FTIR) spectroscopy was used to confirm that losartan potassium and the chosen superdisintegrants worked well together. This was done on separate samples of losartan and banana powder, as well as their physical mixtures with sodium starch glycolate. All formulations underwent assessment for both pre-compression and post-compression characteristics, including parameters like tablet thickness, hardness, friability, weight consistency, disintegration time, wetting time, uniformity of drug content, and in-vitro dissolution performance. Among the tested batches, formulations F5 and F6—which combined banana powder with sodium starch glycolate in ratios of 4:1 and 1:1, respectively—stood out. These two formulations demonstrated rapid disintegration, robust mechanical strength, and an excellent drug release profile. The study found that natural banana powder works effectively as a superdisintegrant. It can be used by itself or mixed with synthetic substances to make efficient orally disintegrating tablets (ODTs).