High blood pressure is a leading cause of heart problems and death worldwide. To control it, people usually need to take blood pressure medicine every day for a long time. However, some patient groups— especially young, elderly, and mentally ill patients—may have trouble swallowing traditional tablet formulations. Furthermore, quickly dissolving oral dosage forms are crucial in situations like motion sickness or the unavailability of water. ODTs offer a promising solution to these problems by enabling the medication to dissolve quickly in the mouth without the need for water, which speeds up the onset of action. Patients are generally treated either with ARBs or ACE inhibitors such as valsartan, telmisartan, enalapril, captopril, ramipril, etc.

Losartan potassium is a medication that blocks angiotensin II receptors and is commonly prescribed for managing high blood pressure. But, it has low oral bioavailability (about 32%) because it is broken down quickly in the first-pass metabolism. Developing an orodispersible tablet (ODT) can enhance the effectiveness of the medication by enabling quicker absorption via the oral mucosa, which allows the drug to avoid both the digestive system and first-pass metabolism in the liver.