Abstract
The conventional mode of drug delivery faces several challenges in the gastric region such as inappropriate drug release and reduction in dose efficacy that hinders the effective drug delivery from conventional dosage forms. Various physiological obstacles such as short gastric residence time and variable gastric emptying time reduce the efficacy of oral dosage forms. The aim is to fabricate formulations that can deliver the drug to the target organ with higher efficacy and increased bioavailability. Hence, a novel approach has been trending for past several years to deliver the drugs effectively in the gastrointestinal area. The system fabricated to enhance the retention of drugs in GIT is known as gastroretentive drug delivery system. GRDDS provides controlled action and enhances the bioavailability of the drug by prolonging the drug release. These are commonly employed for various gastrointestinal disorders and for site-specific drug delivery. This review summarizes various gastroretentive drug delivery approaches such as magnetic system, floating drug delivery system, bioadhesion etc and discusses the future prospects of GRDDS.