The oral cavity serves as an attractive pharmaceutical delivery target, with the buccal mucosa circumventing gastric acid degradation and first-pass hepatic metabolism to enhance drug bioavailability. Salivary flow modulates the pharmacokinetic profile of buccal films, while the inherent mucin layer enables mucoadhesive formulations to establish prolonged residence time through polymer-mucosal interactions. This intimate contact between the pharmaceutical agent and epithelium promotes enhanced permeation and therapeutic efficacy. Strategic formulation engineering neutralizes pH-related challenges and modulates transmucosal permeability through excipient selection to optimize drug transport. Buccal patch formulations employ a bilayered architecture with a drug-loaded polymeric matrix cast onto a backing substrate, complemented by an occlusive backing layer that prevents reverse diffusion and maintains formulation integrity.