Methylcobalamin is a medication commonly prescribed for anemia conditions linked to thick or excessive mucus production.
The sustained-release tablets of Methylcobalamin are prepared using the wet granulation technique. A total of 6 batches were prepared. Dissolution profile and absorption or release of drug within 12 hours. Identification of drug purity was done through FTIR. The FTIR analysis showed that the spectra of the pure drug and the formulation ingredients were largely similar. The FTIR profile of the drug matched the reference spectrum for pure Methylcobalamin, confirming its purity.

The Tapped density of various formulation were varies between 0.55-0.70 (gm/ml). According to the post compression parameter of all formulations are given as well as following. In the prepared formulations, tablet hardness was consistently above 2.0 kg/cm2, reflecting adequate mechanical strength. Additionally, the friability values for formulations 1 through 6 were all below 1%, demonstrating that the tablets possessed excellent resistance to abrasion and maintained their integrity.

Among the sustained release Methylcobalamin tablets, formulation F-5 demonstrated the best performance, as it released at least 90% of the drug within 12 hours.