Cyanocobalamin Extended Release tablet final formulation was pre-pared wet granulation method using Polymer System. The pre-compression para-meter values that were assessed & optimised showed good free-flowing properties and fell within the specified ranges. The post-compression characteristics, including hard-ness, friability, & wt. fluctuation, in vitro disintegration time, and drug content for preparation of tablets have been evaluated. The present investigation was under-taken to fabricate & evaluate a Release tablet of Cyano-cobalamin by wet granulation method. All the formulations were subjected to Accelerated stability program, under stress condition to study the effect of temperature and humidity as guidelines. It is evident that the most of the Extended Release tablets were unaffected in respect of colour stability after 3 months. No appreciable change in physical characteristics, size & shape, & drug content was observed even after the evaluation for 3months storage. No appreciable change in physical characteristic, weight variation, hardness, thickness, % friability, % drug content and in-vitro drug release amount was observed even after the evaluation for 3- months’ storage. Oral administration of dosage form should lead to appropriate distribution & show activity of therapeutic moiety depending on the characteristic of dosage form and drug.  Among these formulated Extended Release tablets of Cyanocobalamin, Formulation (F5) was found to be best because release of drug in 12 Hours was found to be NLT 90.0 %.