The aim of the current study is to evaluate the anti-inflammatory activity of novel vesicular carrier, guggulosomes bearing ketoprofen. KTF-loaded gullulosomes NPs were prepared by lipid film hydration method with different ratios of polymer and constant amount of Drug further incorporated into Carbopol gel. The NPs of guggulosomes were studied by entrapment efficiency, particle size, zeta potential and surface morphology, using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), . In vitro drug release from NPs was also assessed by a Frange diffusion cell method. Prepared guggulosomal gel were characterized by viscosity, Spreadability, pH, Homogeneity and % drug content, Extrudability, Entrapment Efficiency (EE%) of gullulosomal gel. The guggulosomes shows all the characteristic peak in ATR-FTIR. The optimized formulation was spherical in shape having particle size ranging 462.6nm with PDI 0.256. zeta potential value range -6.01(mV).The entrapment efficiency of guggulosomes was found to be between 34.32 ± 1.716 and 75.96 ± 3.798 and the average size was about 75.14 to 173 nm , and the viscosity lies between 6392±319.6 to 1175±58.75,and extrudability are found to be Good and %drug content of optimized formulation is 96.27±0.962 and homogeneity is found good appearance and good elegance,  pH of all formulation lies between 5.9 to 6.8 , Spreadability is found to be 1365±0.445 to 20.84±0.239. The drug released from NP formulations was between 69.98% and 89% upon 24 hours, which indicated improved sustained drug release characteristics. These results suggested