A simple, rapid, and reliable reverse-phase high-performance liquid chromatographic method was developed and validated for the simultaneous estimation of polmacoxib and paracetamol in combined tablet dosage form. No official pharmacopoeial method is available for this combination, highlighting the need for a validated analytical procedure. Chromatographic separation was achieved on a C18 column under optimized isocratic conditions with UV detection at a selected wavelength. The developed method provided good resolution with symmetrical peaks and acceptable retention times. Linearity was observed over the selected concentration ranges with correlation coefficients close to unity. Accuracy and precision studies showed satisfactory recovery and low percentage Relative Standard Deviation values. The method was found specific, robust, economical, and suitable for routine quality control analysis of the combined tablet formulation.