Background: Osteoarthritis is the most prevalent joint disease worldwide and its management still depends heavily on oral non-steroidal anti-inflammatory drugs, whose gastrointestinal and cardiovascular risks limit long-term use. Boswellic acids, the pentacyclic triterpenic acids of Boswellia serrata, inhibit the 5-lipoxygenase pathway and other inflammatory mediators central to osteoarthritis, but their extreme lipophilicity and poor oral bioavailability restrict clinical translation. A transdermal nanoemulgel is a rational way to deliver such a molecule to a superficial joint while bypassing first-pass metabolism. Objective: To profile the five principal boswellic acid congeners computationally, to predict their suitability for transdermal delivery, to test whether their molecular targets are over-represented among osteoarthritis-associated genes, and to translate the resulting property profile into a defensible nanoemulgel formulation-design rationale. Methods: Physicochemical descriptors and drug-likeness were calculated in RDKit for the five boswellic acids and two reference topical non-steroidal anti-inflammatory drugs. The steady-state skin permeability coefficient was predicted with the Potts-Guy model. Literature-compiled boswellic acid targets were intersected with an osteoarthritis gene set and the overlap tested by the hypergeometric distribution. All results are computational predictions; no experimental determination was performed. Results: The boswellic acids were compact, rigid and highly lipophilic (calculated logP 6.41 to 7.80, topological polar surface area 57.53 to 80.67 square angstrom, one to two rotatable bonds). Predicted log Kp values ranged from -1.02 to -0.20 cm/h, higher than diclofenac (-1.41) and ibuprofen (-1.78), a level of favourable intrinsic stratum-corneum permeability that is offset by very low aqueous solubility. Sixteen predicted targets intersected the osteoarthritis gene set in twelve genes, a 405-fold enrichment over chance (hypergeometric p = 3.94 x 10^-31), with 5-lipoxygenase the most connected node. Conclusion: The computed profile supports a solubilising lipid nanoemulgel as a mechanistically justified transdermal strategy for boswellic acids in osteoarthritis, and identifies the specific compound and targets that bench validation should address.